Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles.
J Enzyme Inhib Med Chem
; 20(5): 503-14, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16335060
ABSTRACT
The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18-fold more potent than BHT (IC50 2.3 x 10(-4) M) with 1.3 x 10(-5) M and 1.2 x 10(-5) M IC50 values, respectively, by interaction of the stable DPPH free radical.
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Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Sequestradores de Radicais Livres
/
Antioxidantes
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article