Accumulation of T cells with potent regulatory properties and restricted Vbeta7-TCR rearrangements in tolerated allografts.
Transplantation
; 80(10): 1476-84, 2005 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-16340794
ABSTRACT
BACKGROUND:
We have previously demonstrated that a short-course treatment with LF15-0195, a 15-deoxyspergualin analogue, induces donor-specific tolerance of cardiac allografts in rats and expansion of splenic CD4CD25 regulatory T cells.METHODS:
To further characterize long-term tolerance in this model, we have analyzed the phenotype, regulatory properties and TCR-Vbeta usage of the T cells infiltrating the tolerated allografts.RESULTS:
We demonstrate that the tolerated allografts express high levels of FoxP3 transcripts and contain a large number of CD4 T cells, half of which express CD25. Moreover, T cells from these tolerated allografts are very powerful at transferring tolerance to a subsequent allograft recipient, demonstrating the presence of potent regulatory T cells at the site of the graft. Interestingly, the T cells infiltrating the tolerated allografts systematically display restricted Vbeta7 TCR rearrangements.CONCLUSION:
These results demonstrate in this model of tolerance, a specific accumulation of T cells with potent regulatory properties and exhibiting restricted Vbeta7-TCR rearrangements at the graft site.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
/
Receptores de Antígenos de Linfócitos T alfa-beta
/
Rearranjo Gênico da Cadeia beta dos Receptores de Antígenos dos Linfócitos T
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Linfócitos T Reguladores
/
Tolerância ao Transplante
/
Guanidinas
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article