Bites of the European pigeon tick (Argas reflexus): Risk of IgE-mediated sensitizations and anaphylactic reactions.
J Allergy Clin Immunol
; 117(1): 190-5, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16387605
ABSTRACT
BACKGROUND:
Local and systemic reactions can occur after bites of Argas reflexus (Argas), a soft tick parasitizing pigeons.OBJECTIVE:
Risk assessment of IgE-mediated sensitizations and systemic reactions after Argas bites.METHODS:
Case histories, skin prick tests (SPTs) with a whole-body extract of Argas containing major allergen Arg r 1, and common inhalants and specific IgE measurements were obtained from 148 subjects who had had Argas bites and 20 volunteers as a control group.RESULTS:
Systemic reactions (urticaria, angioedema, dyspnea, cardiovascular dysregulation, unconsciousness) were reported in 12 of 148 (8%); 146 of 148 (99%) had local reactions. Atopy was found in 37 of 146 (25%) with local reactions and 3 of 12 (25%) with systemic reactions. SPT to Argas was positive in 24 of 148 (16%) with a high proportion of atopics 10 of 24 (42%); specific IgE to Argas was detectable in 12 of 135 (8% of 148) with moderate concordance to systemic reactions. No positive SPT or specific IgE results to Argas were obtained in the control group. Immunoblotting of 23 sera revealed an IgE-binding protein in 19 of 23 sera (82%) at 22 kd, indicating a major allergen of Argas.CONCLUSION:
Severe anaphylactic reactions were infrequently (approximately 8%) found after bites of the soft tick Argas reflexus. Atopy is a risk factor for skin sensitizations to Argas, but not for systemic reactions after bites by Argas. Using a whole-body extract of Argas, diagnosis through SPT and specific IgE is hampered by false-negative and irrelevant positive results, particularly in atopy.
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Base de dados:
MEDLINE
Assunto principal:
Columbidae
/
Mordeduras e Picadas
/
Imunoglobulina E
/
Argas
/
Anafilaxia
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article