Studies on diagnostic potential of secretory antigens of Mycobacterium bovis.
Indian J Exp Biol
; 44(1): 14-8, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16430085
ABSTRACT
Culture filtrate proteins (CFPs) of M. bovis were produced by culturing the organism for a period of 3 weeks. These CFPs elicited a good delayed hypersensitivity (DTH) reaction in cattle and guinea pig. However, CFPs showed least cross-reactivity when tested in guinea pigs sensitized with M. bovis BCG and M. phlei. CFPs were found to be well recognized by T-cells of single intradermal test (SIDT) positive cattle and were also sero-reactive. Lymphocyte transformation assay revealed the culture filtrate antigens as major T-cell antigens. CFPs induced a good interferon gamma release as compared to conventional antigen, PPD, thereby highlighting their diagnostic capabilities.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose Bovina
/
Mycobacterium bovis
/
Antígenos de Bactérias
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article