Herpes simplex virus type 2 (HSV-2) seroprevalence at the time of HIV-1 diagnosis and seroincidence after HIV-1 diagnosis in an ethnically diverse cohort of HIV-1-infected persons.
Sex Transm Dis
; 33(2): 96-101, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16432480
ABSTRACT
OBJECTIVE:
The objective of this study was to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence > or =1 year after HIV-1 diagnosis.METHODS:
HSV type-specific antibodies were detected by enzyme immunoassay.RESULTS:
The cohort comprised 850 adults diagnosed HIV-positive in 1986-2001 and followed for a median of 3 years. HSV-2 seroprevalence was 63% (95% confidence interval [CI], 60-66%) and was associated with female gender, heterosexual risk group, black ethnicity, and older age. HSV-2 seroincidence was 1.8 per 100 person-years (95% CI, 0.8-2.8) and was associated with other sexually transmitted diseases, including human papilloma virus infection (P = 0.005) and gonorrhea (P = 0.05). A diagnosis of genital herpes was made in 21% HSV-2-seropositive persons and was more likely in those who tested HIV-positive before 1997 (adjusted odds ratio, 5.11; 95% CI, 3.28-7.98; P = 0.0001).CONCLUSIONS:
Results confirm the epidemiologic association between HIV-1 and HSV-2. HSV-2 seroconversion was a marker of high-risk sexual behavior. The likelihood of developing symptoms of genital herpes declined from 1997 onward.
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Base de dados:
MEDLINE
Assunto principal:
Herpes Genital
/
Infecções por HIV
/
Herpesvirus Humano 2
/
Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article