Sirolimus in de novo heart transplant recipients with severe renal impairment.
Transpl Int
; 19(3): 245-8, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16441775
ABSTRACT
Two patients with end-stage heart failure and advanced renal dysfunction (under chronic dialysis therapy) underwent heart transplantation. In order to avoid further renal impairment, a calcineurine inhibitor-free immunosuppression regimen based on the sirolimus was used. Although temporary perioperative support with hemofiltration and dialysis was needed, both patients eventually regained a reasonable renal function with no episodes of clinical rejection and normal cardiac function at 13 and 11 months, respectively, after transplantation. Sirolimus-based immunosuppression might be an interesting alternative to calcineurine inhibitors in the management of patients with significant renal impairment.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
/
Transplante de Rim
/
Sirolimo
/
Imunossupressores
/
Nefropatias
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article