Structure and interaction modes of thrombin.
Blood Cells Mol Dis
; 36(2): 122-30, 2006.
Article
em En
| MEDLINE
| ID: mdl-16480903
ABSTRACT
Any vascular injury triggers the burst-like release of the trypsin-like serine proteinase alpha-thrombin. Thrombin, the main executioner of the coagulation cascade, exhibits procoagulant as well as anticoagulant and antifibrinolytic properties, very specifically interacting with a number of protein substrates, receptors, cofactors, inhibitors, carbohydrates, and modulators. A large number of crystal structures of alpha-thrombin have shown that the thrombin surface can be subdivided into several functional regions, which recognize different substrates, inhibitors, and mediators with high specificity.
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Base de dados:
MEDLINE
Assunto principal:
Trombina
/
Homeostase
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article