Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Acta Pharmacol Sin
; 27(3): 259-72, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16490160
ABSTRACT
With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.
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Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Analgésicos não Narcóticos
/
Hepatócitos
/
Fígado
/
Hepatopatias
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article