Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators.
Bioorg Med Chem
; 14(13): 4490-518, 2006 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-16513356
ABSTRACT
Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.
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Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Proteínas Serina-Treonina Quinases
/
Cicloexanos
/
Complexos Multienzimáticos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article