Improved access to 2-O-monobenzyl ethers of beta-cyclodextrin as precursors of catalysts for organophosphoryl esters hydrolysis.
Carbohydr Res
; 341(7): 935-40, 2006 May 22.
Article
em En
| MEDLINE
| ID: mdl-16530173
ABSTRACT
A comparative study of reaction conditions was performed for the synthesis of a 2-O-monobenzyl ether of cyclomaltoheptaose (beta-CD). Optimal conditions involved sodium ethoxide in Me(2)SO and benzyl bromide. The methodology was extended to the preparation of various 2(I)-O-iodobenzyl and 2(I)-O-carboxymethylbenzyl derivatives of beta-CD including a 3-carboxymethyl-4-iodobenzyl derivative of interest as precursor of an enzyme mimic to degrade the organophosphoryl ester diethyl 4-nitrophenyl phosphate (paraoxon).
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Base de dados:
MEDLINE
Assunto principal:
Paraoxon
/
Beta-Ciclodextrinas
/
Ésteres
/
Éteres
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article