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Improved access to 2-O-monobenzyl ethers of beta-cyclodextrin as precursors of catalysts for organophosphoryl esters hydrolysis.
Masurier, Nicolas; Estour, François; Lefèvre, Bertrand; Brasme, Bernard; Masson, Patrick; Lafont, Olivier.
Afiliação
  • Masurier N; UMR 6014 CNRS, Université de Rouen, INSA de Rouen, Laboratoire de Pharmacochimie, U.F.R. de Médecine et de Pharmacie, 22 Boulevard Gambetta, F-76183 Rouen, France.
Carbohydr Res ; 341(7): 935-40, 2006 May 22.
Article em En | MEDLINE | ID: mdl-16530173
ABSTRACT
A comparative study of reaction conditions was performed for the synthesis of a 2-O-monobenzyl ether of cyclomaltoheptaose (beta-CD). Optimal conditions involved sodium ethoxide in Me(2)SO and benzyl bromide. The methodology was extended to the preparation of various 2(I)-O-iodobenzyl and 2(I)-O-carboxymethylbenzyl derivatives of beta-CD including a 3-carboxymethyl-4-iodobenzyl derivative of interest as precursor of an enzyme mimic to degrade the organophosphoryl ester diethyl 4-nitrophenyl phosphate (paraoxon).
Assuntos
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Base de dados: MEDLINE Assunto principal: Paraoxon / Beta-Ciclodextrinas / Ésteres / Éteres Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Paraoxon / Beta-Ciclodextrinas / Ésteres / Éteres Idioma: En Ano de publicação: 2006 Tipo de documento: Article