A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 16(11): 2900-4, 2006 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-16554152
ABSTRACT
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic properties when dosed orally in rats and in monkeys. This compound was demonstrated to be efficacious against replication of simian-human immunodeficiency virus (SHIV) 89.6P in infected rhesus macaques.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Integrase de HIV
/
Naftiridinas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article