Voriconazole therapeutic drug monitoring.

Smith, J; Safdar, N; Knasinski, V; Simmons, W; Bhavnani, S M; Ambrose, P G; Andes, D

Smith, J; Safdar, N; Knasinski, V; Simmons, W; Bhavnani, S M; Ambrose, P G; Andes, D.

Afiliação

Smith J; University of Wisconsin, Department of Medicine, Madison, WI 53792, USA.

Antimicrob Agents Chemother ; 50(4): 1570-2, 2006 Apr.

Article em En | MEDLINE | ID: mdl-16569888

ABSTRACT

ABSTRACT

We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P<0.025) between disease progression and drug concentration was detected. Favorable responses were observed in 10/10 patients with concentrations above 2.05 microg/ml, while disease progressed in 44% (n=18) of patients with concentrations below 2.05 microg/ml.

Assuntos

Antifúngicos/sangue; Monitoramento de Medicamentos; Pirimidinas/sangue; Triazóis/sangue; Adulto; Idoso; Progressão da Doença; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Estudos Retrospectivos; Voriconazol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazóis / Monitoramento de Medicamentos / Antifúngicos Idioma: En Ano de publicação: 2006 Tipo de documento: Article

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