Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.
Clin Infect Dis
; 42(8): 1067-72, 2006 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-16575721
ABSTRACT
BACKGROUND:
During the period of 1996-1999, we prospectively monitored 243 Javanese adults and children after arriving in Papua, Indonesia, and microscopically documented each new case of malaria by active surveillance.METHODS:
In a randomized, open-label, comparative malaria treatment trial, 72 adults and 50 children received chloroquine for each incident case of malaria, and 74 adults and 47 children received mefloquine.RESULTS:
Among 975 primary treatment courses, the cumulative 28-day curative efficacies were 26% and 82% for chloroquine against Plasmodium falciparum malaria and Plasmodium vivax malaria, respectively. Mefloquine cure rates were far superior (96% against P. falciparum malaria and 99.6% against P. vivax malaria).CONCLUSIONS:
Mefloquine is a useful alternative treatment for P. vivax malaria and P. falciparum malaria in areas such as Papua, where chloroquine is still recommended as the first-line therapeutic agent.
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Base de dados:
MEDLINE
Assunto principal:
Mefloquina
/
Malária Vivax
/
Malária Falciparum
/
Antimaláricos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article