Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines.
Vaccine
; 24(20): 4328-32, 2006 May 15.
Article
em En
| MEDLINE
| ID: mdl-16581163
ABSTRACT
We evaluated in a prospective study the immune response of naïve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p<0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas de Produtos Inativados
/
Vacinas contra Hepatite A
/
Anticorpos Anti-Hepatite A
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article