A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.
Nat Neurosci
; 9(5): 599-601, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16604067
ABSTRACT
Acetylcholine, a major excitatory neurotransmitter in Caenorhabditis elegans, is transported into synaptic vesicles by the vesicular acetylcholine transporter encoded by unc-17. The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain. These results suggest an association of vesicular soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) components with vesicular neurotransmitter transporters.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Caenorhabditis elegans
/
Proteínas Vesiculares de Transporte de Acetilcolina
/
Proteínas R-SNARE
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article