Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait.
Am J Trop Med Hyg
; 74(4): 578-84, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16606987
ABSTRACT
The high frequencies of both alpha+ thalassemia and the sickle cell trait (hemoglobin AS [HbAS]) found in many tropical populations are thought to reflect selection pressure from Plasmodium falciparum malaria. For HbAS, but not for alpha+ thalassemia, protection appears to be mediated by the enhanced phagocytic clearance of ring-infected erythrocytes. We have investigated the genotype-specific distributions of peripheral blood leukocyte populations in two groups of children living on the coast of Kenya a group of healthy P. falciparum parasite-negative children sampled at cross-sectional survey during a period of low malaria transmission, and a group of children attending the hospital with acute malaria. We report distinctive distributions of peripheral blood myeloid dendritic cells and monocytes in children with alpha+ thalassemia and HbAS during healthy periods and disease, and suggest ways in which these might relate to the mechanisms of protection afforded by these conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Traço Falciforme
/
Malária Falciparum
/
Talassemia alfa
/
Células Mieloides
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article