Novel treatments of schizophrenia: targeting the neurotensin system.
CNS Neurol Disord Drug Targets
; 5(2): 205-18, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16611093
ABSTRACT
Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Encéfalo
/
Neurotensina
/
Receptores de Neurotensina
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article