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Modulation of RNA polymerase core functions by basal transcription factor TFB/TFIIB.
Werner, Finn; Wiesler, Simone; Nottebaum, Sven; Weinzierl, Robert O J.
Afiliação
  • Werner F; Imperial College London, Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK.
Biochem Soc Symp ; (73): 49-58, 2006.
Article em En | MEDLINE | ID: mdl-16626286
The archaeal basal transcriptional machinery consists of TBP (TATA-binding protein), TFB (transcription factor B; a homologue of eukaryotic TFIIB) and an RNA polymerase that is structurally very similar to eukaryotic RNA polymerase II. This constellation of factors is sufficient to assemble specifically on a TATA box-containing promoter and to initiate transcription at a specific start site. We have used this system to study the functional interaction between basal transcription factors and RNA polymerase, with special emphasis on the post-recruitment function of TFB. A bioinformatics analysis of the B-finger of archaeal TFB and eukaryotic TFIIB reveals that this structure undergoes rapid and apparently systematic evolution in archaeal and eukaryotic evolutionary domains. We provide a detailed analysis of these changes and discuss their possible functional implications.
Assuntos
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Base de dados: MEDLINE Assunto principal: RNA Polimerases Dirigidas por DNA / Proteínas Arqueais / Fator de Transcrição TFIIB Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: RNA Polimerases Dirigidas por DNA / Proteínas Arqueais / Fator de Transcrição TFIIB Idioma: En Ano de publicação: 2006 Tipo de documento: Article