Torsades de pointes upon fluconazole administration in a patient with acute myeloblastic leukemia.
Am J Hematol
; 81(5): 366-9, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16628725
ABSTRACT
Prolonged QT syndrome often causes torsades de pointes (Tdp), a potentially lethal arrhythmia. A 55-year-old woman with M4Eo who was receiving consolidation chemotherapy had an episode of prolonged QT and Tdp following fluconazole (FCZ) administration. Intravenous supplementation of magnesium sulfate and multiple attempts at electrocardioversion led to recovery from the arrhythmia. FCZ appears to contribute to the development of QT prolongation, in particular with low concentrations of serum potassium or magnesium. Although mechanisms of Tdp development in patients with QT prolongation remain to be determined, it is possible that FCZ administration leads to manifestation of Tdp. Special cautions should be exercised upon the emergence of QT prolongation following FCZ administration.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Oportunistas
/
Leucemia Mieloide Aguda
/
Fluconazol
/
Torsades de Pointes
/
Micoses
/
Antifúngicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article