[Morphological study of the myocardium of mice infected with Coxsackie B1 virus during the treatment with an immunomodulating drug T-activin]. / Morfologicheskoe izuchenie miokarda myshei, infitsirovannykh virusom Koksaki B1, na fone lecheniia immunomoduliruiushchim preparatom T-aktivinom.

ABSTRACT

The study was undertaken to examine myocardial morphological alterations in mice treated with T-activin in different periods of viral myocarditis. Two-month BALB/C mice of both sexes were used in the experiments, which were intraperitoneally given 0.2 ml Coxsackie B1 virus in a titer of 10(-3)-10(-7) D50 ml. The material was taken 3, 5, 7, 9, 15, and 30 days following infection. Intact mice and animals given culture fluid were applied as controls. T-activin was subcutaneously injected in a dose of 0.2 ml at the rate of 0.01 mg per kg body weight on day 5 after virus infection for 5 days. The predominance of an alterative component of inflammation (dystrophic, necrobiotic and necrotic changes) over proliferative processes was ascertained to be common to all periods of infection. T-activin administration attenuated myocardial damage.