The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.
Haematologica
; 91(5): 711-2, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16670078
ABSTRACT
We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Inibidores de Proteases
/
Pirimidinas
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Saquinavir
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article