Adjuvant effect of lemnan, pectic polysaccharide of callus culture of Lemna minor L. at oral administration.
Immunopharmacol Immunotoxicol
; 28(1): 141-52, 2006.
Article
em En
| MEDLINE
| ID: mdl-16684673
ABSTRACT
A pectic polysaccharide, lemnan LMC, was extracted from the callus of duckweed Lemna minor L. and was tested for adjuvant properties at oral administration with protein antigen. Mice were orally immunized thrice with weekly interval with free hen's egg lysozyme or lysozyme with LMC. Lemnan LMC was shown to increase delayed type hypersensitivity and serum antilysozyme IgG responses. LMC was established to increase levels of both serum IgG1 and IgG2a subclasses. The concentration of malondialdehyde and myeloperoxidase activity were found to be higher in the tissue samples obtained from small intestine of mice immunized with mixture of lysozyme/LMC than those immunized with lysozyme only. Thus, lemnan appeared to be useful as the adjuvant for oral immunization.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Adjuvantes Imunológicos
/
Pectinas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article