Tachykinin receptors as drug targets for motility disorders.
Dig Dis
; 24(1-2): 83-90, 2006.
Article
em En
| MEDLINE
| ID: mdl-16699266
ABSTRACT
The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.
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Base de dados:
MEDLINE
Assunto principal:
Fármacos do Sistema Nervoso Autônomo
/
Fármacos Gastrointestinais
/
Receptores de Taquicininas
/
Gastroenteropatias
/
Motilidade Gastrointestinal
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article