Isoquino[4,5-bc]acridines: design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability.
J Photochem Photobiol B
; 84(3): 221-6, 2006 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16714120
ABSTRACT
Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 microM and cleaved DNA from form I to 100% form II by 50 microM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.
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Base de dados:
MEDLINE
Assunto principal:
Acridinas
/
DNA de Neoplasias
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article