In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor.
Acta Pharmacol Sin
; 27(6): 754-9, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16723096
ABSTRACT
AIM:
To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time.METHODS:
Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method.RESULTS:
The average diameter of the gelatin particle-PLGA microsphere composite was 5-18 mum, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation.CONCLUSION:
A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
/
Polímeros
/
Fator 2 de Crescimento de Fibroblastos
/
Ácido Láctico
/
Gelatina
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article