Growth impairment after ifosfamide-induced nephrotoxicity in children.
Pediatr Blood Cancer
; 48(5): 571-6, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-16755549
ABSTRACT
BACKGROUND:
The goal of this study was to analyze long-term consequences of ifosfamide-induced nephrotoxicity on growth and renal function in children treated for cancer. PROCEDURE In a retrospective study, departments for pediatric oncology and nephrology in Germany, Austria, and Switzerland were asked to report patients with serious long-term nephrotoxicity after ifosfamide-treatment. Data at first appearance of renal dysfunction and at the last renal examination were collected using a standardized questionnaire.RESULTS:
Fifty-nine patients with tubulopathy (35 severe, 24 moderate) following ifosfamide therapy were eligible for analysis of long-term outcome (median follow-up 4 years, range 1.1 to 12.9). Median height standard deviation score was significantly reduced at renal diagnosis, and at last renal examination (-1.7 and -2.1 respectively, P < 0.01 at each point in time). Patients with tubulopathy also had stunted growth in comparison with a control group of cancer patients without renal disease (mean difference at last examination 7.3 cm (95% confidence interval 2.5 to 12.1 cm). In patients with severe tubulopathy, glomerular filtration rate deteriorated significantly over time. End-stage renal disease was reported in one patient only, not solely caused by ifosfamide.CONCLUSION:
Depending on the extent of tubular dysfunction, patients with ifosfamide-induced nephrotoxicity experienced significant growth impairment and a slow decline in glomerular filtration rate.
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Base de dados:
MEDLINE
Assunto principal:
Antineoplásicos Alquilantes
/
Transtornos do Crescimento
/
Ifosfamida
/
Nefropatias
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article