3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Bioorg Med Chem Lett
; 16(17): 4620-3, 2006 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16784844
A series of 3-aryl-4-hydroxyquinolin-2(1H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC(50) = 1.4 microM, SAR studies led to compounds with more than 70-fold increase in potency (IC(50) < 20 nM).
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Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Inibidores Enzimáticos
/
Ácido Graxo Sintases
/
Hidroxiquinolinas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article