Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats.
Infect Immun
; 74(7): 4387-9, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16790818
ABSTRACT
In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cryptosporidium parvum
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Criptosporidiose
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Hipersensibilidade
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Jejuno
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article