Capecitabine-induced hypertriglyceridemia: a report of two cases.
Anticancer Res
; 26(3B): 2249-51, 2006.
Article
em En
| MEDLINE
| ID: mdl-16821596
ABSTRACT
BACKGROUND:
Capecitabine is a tumor-activated oral fluoropyrimidine with established antitumor activity in breast and colorectal cancer. Hypertriglyceridemia associated with this drug has rarely been reported in the literature. CASE REPORT This is a report of two patients who developed capecitabine-induced severe hypertriglyceridemia, together with an increase in total cholesterol levels. The first patient developed hyperlipidemia during long-term capecitabine treatment in combination with trastuzumab for metastatic breast carcinoma (triglycerides from 219 mgldl to 1409 mg/dl, 543% increase; cholesterol from 239 mg/dl to 363 mg/dl, 52% increase). The second patient developed abnormalities in the lipid profile after the second cycle of chemotherapy with capecitabine and oxaliplatin for metastatic colorectal cancer (triglycerides from 101 mg/dl to 1510 mg/dl, 1395% increase; cholesterol from 203 mg/dl to 310 mgldl, 52% increase). An analysis of the possible underlying pathogeneic mechanisms is provided.CONCLUSION:
Physicians should be aware of the possibility of dyslipidemia, particularly hypertriglyceridemia, following treatment with capecitabine.
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Base de dados:
MEDLINE
Assunto principal:
Hipertrigliceridemia
/
Desoxicitidina
/
Antimetabólitos Antineoplásicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article