[Screening and analysis of coding SNPs of HLA-DQA1 gene involved in susceptibility for cervical cancer].
Ai Zheng
; 25(7): 906-10, 2006 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-16831288
ABSTRACT
BACKGROUND & OBJECTIVE:
Polymorphisms of human leukocyte antigen (HLA) gene play an important role in the development of cervical cancer. This study was to screen single nucleotide polymorphisms (SNPs) of HLA-DQA1 gene involved in susceptibility of cervical cancer by a bioinformatics approach, and analyze their correlations to abnormal gene functions.METHODS:
SNPs of HLA-DQA1 were screened from a public database dbSNP by SNPper software, and relevant FASTA subsequences were also obtained from dbSNP. PARSESNP software was used to analyze cSNPs.RESULTS:
Two SNPs, rs9272693 and rs9272703, which may induce mis-sense mutation, were identified in codon region of HLA-DQA1 gene. A PSSM difference>10 was used to predict deleterious mutation.CONCLUSIONS:
SNPper software in combination with PARSESNP software could be used to analyze SNPs of HLA-DQA1 gene and select the variants in a conserved region, and it provides an evaluation criterion. But the results need to be verified in cervical cancer patients and control populations.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-DQ
/
Neoplasias do Colo do Útero
/
Polimorfismo de Nucleotídeo Único
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article