Search of antitubercular activities in tetrahydroacridines: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 16(19): 5144-7, 2006 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-16870429
ABSTRACT
A series of 9-substituted tetrahydroacridines were synthesized by nucleophilic substitution of chloro group with different nucleophiles in 9-chlorotetrahydroacridine (2). The latter could be obtained by POCl(3) mediated cyclization of the intermediate enamine, which in turn, was prepared by acid catalyzed condensation of anthranilic acid and cyclohexanone. Most of the compounds on antitubercular evaluation against M. tuberculosis H37 Rv and H37 Ra strains exhibited potent activities with MIC 6.125-0.78 microg/mL comparable to the standard drugs.
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Base de dados:
MEDLINE
Assunto principal:
Acridinas
/
Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article