Effect of phosphonoformic acid in the development of bovine embryos in vitro.
Vet Ther
; 7(2): 156-66, 2006.
Article
em En
| MEDLINE
| ID: mdl-16871497
ABSTRACT
This research evaluated the ability of phosphonoformic acid to inhibit bovine herpesvirus 1 (BHV-1) in cumulus cells commonly used in co-culture with bovine in vitro-produced embryos. At 200 and 400 microg/ml, phosphonoformic acid inhibited 4 logs of BHV-1. Subsequently, phosphonoformic acid (200 and 400 microg/ml) added to both in vitro fertilization and culture medium resulted in a decrease in the proportion of developed blastocysts, and the number of cells per blastocyst was lower in the treated embryos. Therefore, while phosphonoformic acid can effectively inhibit replication of BHV-1 in co-culture cells, it also inhibits development of in vitro-produced bovine embryos.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Bovinos
/
Foscarnet
/
Herpesvirus Bovino 1
/
Desenvolvimento Embrionário
/
Embrião de Mamíferos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article