ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9.
J Immunol
; 177(4): 2356-64, 2006 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-16887997
ABSTRACT
We report in this study that B7h, the ligand for the ICOS costimulatory receptor, is rapidly shed from mouse B cells following either ICOS binding or BCR engagement. Shedding occurs through proteolytic cleavage that releases the extracellular ICOS-binding region of B7h. Prior exposure of B7h-expressing APCs to ICOS-expressing cells inhibits their subsequent ability to costimulate IFN-gamma and IL-4 production from CD4+ T cells. Shedding is regulated as TLR7/8 and TLR9 ligands inhibit B7h shedding. A shedding-resistant B7h mutant elicits greater costimulation of IFN-gamma production from CD4+ T cells than does wild-type B7h. These data define shedding of B7h as a novel mechanism for controlling costimulatory signaling by B7-CD28 family members that is regulated on B cells by TLR signaling.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Linfócitos B
/
Proteínas
/
Antígenos de Diferenciação de Linfócitos T
/
Receptor Toll-Like 9
/
Receptor 7 Toll-Like
/
Receptor 8 Toll-Like
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article