Inactivation of human immunodeficiency virus type 1 in tissue culture fluid and in genital secretions by the spermicide benzalkonium chloride.
J Clin Microbiol
; 28(1): 156-8, 1990 Jan.
Article
em En
| MEDLINE
| ID: mdl-1688873
ABSTRACT
We have shown that the spermicidal agent benzalkonium chloride can exert a direct inhibitory effect on the viral reverse transcriptase activity of human immunodeficiency virus type 1 (HIV-1) when utilized at concentrations of 0.05% and higher. Exposure of HIV-1 to this disinfectant at concentrations of more than 0.05% was able to completely destroy viral infectivity, as assessed on susceptible target cells. We have further shown that HIV-1, which is present in both seminal and genital secretions, can be inactivated in such fluids by direct exposure to benzalkonium chloride.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Espermicidas
/
Compostos de Benzalcônio
/
HIV-1
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article