Physical and psychological co-morbidity in irritable bowel syndrome: a matched cohort study using the General Practice Research Database.
Aliment Pharmacol Ther
; 24(5): 879-86, 2006 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16918893
ABSTRACT
BACKGROUND:
Irritable bowel syndrome is a common problem known to have a complex relationship with psychological disorders and other physical symptoms. Little information, however, is available concerning physical and psychological comorbidity in irritable bowel syndrome patients studied over an extended period.AIM:
To evaluate physical and psychological morbidity 2 years before and during 6 years after the time of diagnosis in incident cases of irritable bowel syndrome and control subjects.METHODS:
A matched cohort study was implemented in 123 general practices using the General Practice Research Database. Irritable bowel syndrome cases (n = 1827) and controls (n = 3654) were compared for 2 years before and 6 years after diagnosis.RESULTS:
The age-standardized incidence of irritable bowel syndrome in patients over 15 years of age was 1.9 per 1,000 in men and 5.8 per 1,000 in women. From 2 years before the date of diagnosis, more irritable bowel syndrome cases (13%) than controls (5%) consulted with depression or were prescribed antidepressant drugs. Consultation and prescription rates for anxiety were also higher before diagnosis, and both anxiety and depression remained prevalent up to 6 years after diagnosis. Asthma, symptoms of urinary tract infection, gall-bladder surgery, hysterectomy and diverticular disease were recorded more frequently in irritable bowel syndrome patients, who were also more likely than controls to be referred to hospital.CONCLUSIONS:
People who are diagnosed with irritable bowel syndrome experience more anxiety and depression and a range of physical problems, compared with controls; they are more likely to be referred to hospital.
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Base de dados:
MEDLINE
Assunto principal:
Bases de Dados Factuais
/
Síndrome do Intestino Irritável
/
Medicina de Família e Comunidade
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article