Structural insights into antibody-mediated mucosal immunity.
Curr Top Microbiol Immunol
; 308: 173-204, 2006.
Article
em En
| MEDLINE
| ID: mdl-16922091
ABSTRACT
The mucosal regions of the body are responsible for defense against environmental pathogens. Particularly in the lumen of the gut, antibody-mediated immune responses are critical for preventing invasion by pathogens. In this chapter, we review structural studies that have illuminated various aspects of mucosal immunity. Crystal structures of IgA1-Fc and IgA-binding fragments of the polymeric immunoglobulin receptor and Fc alphaRI, combined with models of intact IgA and IgM from solution scattering studies, reveal potential mechanisms for immune exclusion and induction of inflammatory responses. Other recent structures yield insights into bacterial mechanisms for evasion of the host immune response.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Imunoglobulina M
/
Imunidade nas Mucosas
/
Mucosa Intestinal
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article