Effect of lactate on functional activity of macrophages under normal conditions and during tumor growth.
Bull Exp Biol Med
; 141(1): 66-9, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16929967
ABSTRACT
Lactate modulated functional activity of macrophages from intact mice and animals with transplantable syngeneic hepatoma 22a. Sodium lactate in a concentration of 6.5 mM in vitro increased functional activity of resident peritoneal macrophages from intact mice. The growth of transplantable syngeneic hepatoma 22a was associated with the absence of correlation between nitrite synthesis by peritoneal macrophages and serum lactate concentration. Therefore, this agent cannot be considered as a systemic activator of macrophages.
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Base de dados:
MEDLINE
Assunto principal:
Macrófagos Peritoneais
/
Carcinoma Hepatocelular
/
Ácido Láctico
/
Neoplasias Hepáticas
/
Nitritos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article