CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant.
Immunol Cell Biol
; 84(6): 543-50, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-16956387
ABSTRACT
The T-cell response to even complex pathogens is often focused on only a handful of immunodominant determinants. Such narrow responses provoke a selective pressure that can drive the emergence of CTL escape variants, raising the question of whether a broader response, targeting multiple non-dominant peptides may be more beneficial. To examine the ability of the T-cell repertoire to respond to non-dominant determinants, we have investigated how mutating the dominant peptide in HSV affects the magnitude of the CD8+ T-cell response. We found that the CTL response to HSV lacking the dominant peptide was only modestly reduced compared with the wild-type virus and, surprisingly, this compensation occurred without any enhancement in the response to an established minor epitope. These findings are supportive of a malleable T-cell repertoire that can elicit strong responses to alternate, unknown determinants in the absence of the dominant response.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Proteínas do Envelope Viral
/
Epitopos Imunodominantes
/
Herpesvirus Humano 1
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article