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DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.
Voso, Maria Teresa; Gumiero, Daniela; D'Alo', Francesco; Guidi, Francesco; Mansueto, Giovanna; Di Febo, Anna Laura; Massini, Giuseppina; Martini, Maurizio; Larocca, Luigi Maria; Hohaus, Stefan; Leone, Giuseppe.
Afiliação
  • Voso MT; Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
Haematologica ; 91(9): 1252-6, 2006 Sep.
Article em En | MEDLINE | ID: mdl-16956827
ABSTRACT
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
Assuntos
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Base de dados: MEDLINE Assunto principal: Medula Óssea / Linfoma Folicular / Proteínas Quinases Dependentes de Cálcio-Calmodulina / Proteínas Reguladoras de Apoptose Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Medula Óssea / Linfoma Folicular / Proteínas Quinases Dependentes de Cálcio-Calmodulina / Proteínas Reguladoras de Apoptose Idioma: En Ano de publicação: 2006 Tipo de documento: Article