Antidepressant principles of the roots of Polygala tenuifolia.
J Nat Prod
; 69(9): 1305-9, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16989524
ABSTRACT
[(125)I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC(50) values of 30.0 and 6.04 microM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.
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Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Plantas Medicinais
/
Polygala
/
Antidepressivos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article