A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion.
Pediatr Surg Int
; 23(6): 595-9, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17063337
ABSTRACT
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Tropomiosina
/
Proteínas Tirosina Quinases
/
Proteínas de Fusão Oncogênica
/
Neoplasias Pulmonares
/
Neoplasias de Tecido Muscular
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article