Core exploration in optimization of chemokine receptor CCR4 antagonists.
Bioorg Med Chem Lett
; 17(3): 679-82, 2007 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-17098428
ABSTRACT
The design, synthesis, and SAR studies of 'core' variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 approximately 10 mg/kg).
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Quimiocinas
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article