Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Bioorg Med Chem Lett
; 17(3): 702-6, 2007 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-17107798
ABSTRACT
A series of tetrahydroisoquinolines acting as dual histamine H3/serotonin transporter ligands is described. A highly regio-selective synthesis of the tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Histamínicos H3
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article