Synthetic peptides in HIV antibody screening and typing.
Ann N Y Acad Sci
; 626: 502-15, 1991.
Article
em En
| MEDLINE
| ID: mdl-1711828
ABSTRACT
PIP: This article reviews the basic method used to define native epitopes from transmembrane proteins and the function of synthetic peptides in HIV screening and typing. Identification of continuous native epitopes from structural protein sequences of HIV-1 and HIV-2 involves the use of systematic scanning epitope technology. Scanning profiles of these two types of HIV demonstrated that there is a highly immunoreactive continuous native epitope region in the transmembrane protein gp41 of HIV-1 as well as in the corresponding region in HV-2 gp34. However, the number of highly immunoreactive regions differs in the structural proteins of the two types of HIV infections. These highly immunoreactive regions, when presented accurately as synthetic antigens in solid-phase enzyme immunoassay, can provide tests that are remarkably appropriate for the early and reliable diagnosis and type-specification of HIV-1 and HIV-2 infections.
Palavras-chave
Americas; Developed Countries; Diseases; Europe; Examinations And Diagnoses; Finland; Hawaii; Hiv Infections; Hiv Serodiagnosis; Italy; Laboratory Examinations And Diagnoses; Mediterranean Countries; North America; Northern America; Northern Europe; Scandinavia; Southern Europe; Summary Report; United States; Viral Diseases
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Anticorpos Anti-HIV
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article