Toxoplasma gondii in human astrocytes in vitro: interleukin (IL)-12 and IL-10 do not influence cystogenesis.
J Parasitol
; 92(5): 1108-10, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-17152962
ABSTRACT
Interleukin (IL)-12, IL-10, and interferon (IFN)-gamma are major cytokines involved in the immune response against Toxoplasma gondii. Nevertheless, the role of IL-12 and IL-10 in the control of parasite replication and cytogenesis is not known yet, whereas the importance of IFN-gamma is documented. Furthermore, it is of paramount importance to study the interaction between T. gondii and cells from the central nervous system, e.g., astrocytes. In this study, we report that IL-12 and IL-10 have no effect on penetration, replication, or cystogenesis of the T. gondii Prugniaud strain in human astrocytes in vitro and do not antagonize the role of IFN-gamma on cystogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Astrócitos
/
Interleucina-10
/
Interleucina-12
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article