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Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein.
Sweenie, Claire H; Mackenzie, Karen J; Rone-Orugboh, Alero; Liu, Michael; Anderton, Stephen M.
Afiliação
  • Sweenie CH; University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
J Neuroimmunol ; 183(1-2): 7-16, 2007 Feb.
Article em En | MEDLINE | ID: mdl-17157925
ABSTRACT
We have assessed the complexity in T cell recognition of the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice. Immunization with the p35-55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35-55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG.
Assuntos
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Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Glicoproteínas / Linfócitos T / Epitopos Imunodominantes / Epitopos de Linfócito T / Memória Imunológica Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Glicoproteínas / Linfócitos T / Epitopos Imunodominantes / Epitopos de Linfócito T / Memória Imunológica Idioma: En Ano de publicação: 2007 Tipo de documento: Article