Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
Nucleosides Nucleotides Nucleic Acids
; 26(1): 83-97, 2007.
Article
em En
| MEDLINE
| ID: mdl-17162589
ABSTRACT
In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Nucleosídeos de Purina
/
Hepacivirus
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article