The persistence of humoral and cellular immunities more than three decades after smallpox vaccination.
Clin Microbiol Infect
; 13(1): 91-3, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17184294
ABSTRACT
This study assessed the persistence of humoral (neutralising antibody titre to vaccinia virus) and cellular (immediate vaccinia-specific interferon (IFN)-gamma-producing T-cell) immunities to smallpox in a Korean population. Individuals who were vaccinated 25-60 years previously had higher neutralising antibody titres (geometric mean titre (GMT) 13.7; 95% CI 11.0-17.2) than vaccinia-naive individuals (GMT 6.7; 95% CI 5.5-8.0; p <0.001). However, there was no significant difference in cellular immunity between individuals vaccinated previously and vaccinia-naive individuals, and only 15% of the individuals vaccinated previously displayed an immediate IFN-gamma-producing effector-memory response in ELISPOT assays.
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Base de dados:
MEDLINE
Assunto principal:
Vaccinia virus
/
Varíola
/
Vacina Antivariólica
/
Linfócitos T
/
Vacinação
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Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article