Sequences involved in brain-specific in vitro transcription from the core promoter of the mouse myelin basic protein gene.
Biochim Biophys Acta
; 1129(1): 83-6, 1991 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-1721839
ABSTRACT
In the previous study, we have shown that a short DNA stretch from -35 to -17 in the core promoter of the mouse myelin basic protein (MBP) gene is mainly responsible for brain-specificity in in vitro transcription. In this study, we found from intensive mutation analysis that the TATA-box sequence at -34 is not critical, but sequences downstream from the TATA-box especially around -20 were important for brain-specificity. The existence of a tissue-specific factor for the MBP core promoter different from the TATA-box-binding factor TFIID is implicated.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Encéfalo
/
Regiões Promotoras Genéticas
/
Proteína Básica da Mielina
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article