Apoptosis during herpes simplex virus infection.
Adv Virus Res
; 69: 67-97, 2007.
Article
em En
| MEDLINE
| ID: mdl-17222692
ABSTRACT
Herpes simplex virus (HSV) infection triggers apoptosis in infected cells. However, proteins synthesized later in infected cells prevent apoptotic cell death from ensuing. In vivo data showing that apoptosis accompanies herpes stromal keratitis and encephalitis suggest that apoptotic modulation plays a role in the development of herpetic disease. Tremendous progress has been made toward identifying the viral factors that are responsible for inducing and inhibiting apoptosis during infection. However, the mechanisms whereby they act are still largely unknown. Recent studies have illustrated a wide diversity in the cellular response to HSV-triggered apoptosis, emphasizing the importance of host factors in this process. Together, these findings indicate that apoptosis during HSV infection represents an important virus-host interaction process, which likely influences viral pathogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Herpes Simples
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article